Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis

J Yarmolinsky; JW Robinson; D Mariosa; V Karhunen; J Huang; N Dimou; N Murphy; K Burrows; E Bouras; K Smith-Byrne; SJ Lewis; TE Galesloot; LA Kiemeney; S Vermeulen; P Martin; D Albanes; L Hou; PA Newcomb; E White; A Wolk; AH Wu; L Le Marchand; AI Phipps; DD Buchanan; MT Landi; V Stevens; Y Wang; D Albanes; N Caporaso; P Brennan; CI Amos; S Shete; RJ Hung; H Bickeböller; A Risch; R Houlston; S Lam; A Tardon; C Chen; SE Bojesen; M Johansson; HE Wichmann; D Christiani; G Rennert; S Arnold; JK Field; O Melander; H Brunnström; G Liu; A Andrew; H Shen; S Zienolddiny; K Grankvist; M Johansson; MD Teare; YC Hong; JM Yuan; P Lazarus; MB Schabath; MC Aldrich; RA Eeles; CA Haiman; Z Kote-Jarai; FR Schumacher; S Benlloch; AA Al Olama; KR Muir; SI Berndt; DV Conti; F Wiklund; S Chanock; CM Tangen; J Batra; JA Clements; H Grönberg; N Pashayan; J Schleutker; SJ Weinstein; CML West; LA Mucci; G Cancel-Tassin; S Koutros; KD Sørensen; EM Grindedal; DE Neal; FC Hamdy; JL Donovan; RC Travis; RJ Hamilton; SA Ingles; BS Rosenstein; YJ Lu; GG Giles; RJ MacInnis; AS Kibel; A Vega; M Kogevinas; KL Penney; JY Park

Journal article

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis

J Yarmolinsky, JW Robinson, D Mariosa, V Karhunen, J Huang, N Dimou, N Murphy, K Burrows, E Bouras, K Smith-Byrne, SJ Lewis, TE Galesloot, LA Kiemeney, S Vermeulen, P Martin, D Albanes, L Hou, PA Newcomb, E White, A Wolk Show all

Ebiomedicine | ELSEVIER | Published : 2024

DOI: 10.1016/j.ebiom.2024.104991

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Abstract

Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls..

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University of Melbourne Researchers

Daniel Buchanan Author

Graham Giles Author

Robert MacInnis Author

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Awarded by Agència de Gestió d'Ajuts Universitaris i de Recerca

Funding Acknowledgements

Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT\100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654).